No definition available.
Allergic contact dermatitis due to drugs in contact with skin
ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
724 |
4. Check minimum number of eventsNone |
724 |
5. Include endpointsNone |
724 |
6. Filter based on genotype QC (FinnGen only) |
707 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Allergic contact dermatitis due to drugs in contact with skin
based on the number of shared cases.
Similar with more cases:
- Allergic contact dermatitis
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5347 | 3692 | 1635 |
| Only index persons | 5018 | 3503 | 1515 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.05 |
| Only index persons | 0.11 | 0.13 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 53.77 | 53.75 | 53.80 |
| Only index persons | 53.05 | 52.95 | 53.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 707 | 497 | 210 |
| Unadjusted period prevalence (%) | 0.17 | 0.20 | 0.11 |
| Median age at first event (years) | 55.51 | 53.13 | 61.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN | 1.27 [1.11, 1.45] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 3292 females with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN | 1.183 [1.01, 1.38] | 0.037 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1473 males with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.
Mortality risk
Mortality risk for people of age
years, who have ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.179% |
| 5 | 0.634% | 1.323% |
| 10 | 1.575% | 3.396% |
| 15 | 3.293% | 6.513% |
| 20 | 5.733% | 11.263% |
Relationships between endpoints
↥Index endpoint: ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN – Allergic contact dermatitis due to drugs in contact with skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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