actinic keratosis: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
14159 |
4. Check minimum number of eventsNone |
14159 |
5. Include endpointsNone |
14159 |
6. Filter based on genotype QC (FinnGen only) |
13737 |
Control definitions (FinnGen only)
Control exclude
L12_RADIATIONRELATEDSKIN
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L57
Name in latin
Keratosis actinica
Similar endpoints
↥List of similar endpoints to
Actinic keratosis
based on the number of shared cases.
Similar with more cases:
- Skin changes due to chronic exposure to nonionizing radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 98072 | 56871 | 40899 |
| Only index persons | 92586 | 54015 | 38571 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.42 | 1.63 | 1.14 |
| Only index persons | 1.77 | 1.99 | 1.47 |
| Median age at first event (years) | |||
| Whole population | 75.63 | 76.14 | 74.92 |
| Only index persons | 75.35 | 75.83 | 74.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 13737 | 7030 | 6707 |
| Unadjusted period prevalence (%) | 3.06 | 2.76 | 3.37 |
| Median age at first event (years) | 72.83 | 71.83 | 73.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACTINKERA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACTINKERA | 0.854 [0.78, 0.93] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.128 |
During the follow-up period (1.1.1998 — 31.12.2019), 15019 out of 48341 females with L12_ACTINKERA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACTINKERA | 0.897 [0.81, 1.0] | 0.043 |
| Birth year | 0.986 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 10872 out of 34016 males with L12_ACTINKERA died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACTINKERA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.161% |
| 5 | 0.498% | 0.92% |
| 10 | 1.172% | 2.322% |
| 15 | 2.169% | 4.474% |
| 20 | 3.887% | 7.46% |
Relationships between endpoints
↥Index endpoint: L12_ACTINKERA – Actinic keratosis
GWS hits: 36
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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