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Tic disorders

Endpoint Browser PheWeb

KRA_PSY_TIC_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F95
  • Hospital discharge: ICD-9 — 3072
  • Hospital discharge: ICD-8 — 30620
  • Cause of death: ICD-10 — F95
  • Cause of death: ICD-9 — 3072
  • Cause of death: ICD-8 — 30620

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 F90-F98
Name in latin Perturbationes ticiformes

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12184 3427 8742
Only index persons 9944 2898 7046
Unadjusted period prevalence (%)
Whole population 0.20 0.10 0.24
Only index persons 0.22 0.11 0.27
Median age at first event (years)
Whole population 9.93 10.84 9.52
Only index persons 10.81 12.11 10.28

-FinnGen-

Key figures

All Female Male
Number of individuals 420 216 204
Unadjusted period prevalence (%) 0.09 0.08 0.10
Median age at first event (years) 14.61 17.26 11.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_TIC_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_TIC_EXMORE 1.34 [0.94, 1.92] 0.111
Birth year 0.994 [0.99, 1.0] 0.182

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 2389 females with KRA_PSY_TIC_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_TIC_EXMORE 1.569 [1.19, 2.07] 0.001
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 6900 males with KRA_PSY_TIC_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_TIC_EXMORE.

N-year risk Females Males
1 0.136% 0.294%
5 0.77% 1.889%
10 1.82% 4.912%
15 3.571% 9.327%
20 6.152% 15.684%

Relationships between endpoints

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Index endpoint: KRA_PSY_TIC_EXMORE – Tic disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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