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Other disorders starting during childhood or adolecense

Endpoint Browser PheWeb

KRA_PSY_CHILDOTH_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F98
  • Hospital discharge: ICD-9 — 307[0|3]|307[6-7]
  • Hospital discharge: excluded ICD-10 — 306[0|6|7]
  • Cause of death: ICD-10 — F98
  • Cause of death: ICD-9 — 307[0|3]|307[6-7]
  • Cause of death: excluded ICD-10 — 306[0|6|7]

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 F90-F98
Name in latin Aliae perturbationes modi se gerendi et emotionales usitate in pueritia sive adolescentia incipientes

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 55731 23463 32234
Only index persons 44976 19158 25818
Unadjusted period prevalence (%)
Whole population 0.80 0.67 0.90
Only index persons 0.87 0.70 0.99
Median age at first event (years)
Whole population 7.78 7.73 7.80
Only index persons 8.60 8.71 8.52

-FinnGen-

Key figures

All Female Male
Number of individuals 1854 1130 724
Unadjusted period prevalence (%) 0.41 0.44 0.36
Median age at first event (years) 10.32 10.79 9.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_CHILDOTH_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_CHILDOTH_EXMORE 2.362 [1.52, 3.66] < 0.001
Birth year 0.998 [0.99, 1.01] 0.593

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 19737 females with KRA_PSY_CHILDOTH_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_CHILDOTH_EXMORE 2.04 [1.64, 2.54] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 295 out of 27303 males with KRA_PSY_CHILDOTH_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_CHILDOTH_EXMORE.

N-year risk Females Males
1 0.148% 0.355%
5 1.312% 2.524%
10 3.386% 6.197%
15 6.909% 11.529%
20 12.806% 18.78%

Relationships between endpoints

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Index endpoint: KRA_PSY_CHILDOTH_EXMORE – Other disorders starting during childhood or adolecense

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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