Emotional disorders starting during childhood or adolecense

KRA_PSY_CHILDEMOT_EXMORE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F93
  • Hospital discharge: ICD-9 3092A|3092B|3133A|3138B|3138C
  • Cause of death: ICD-10 F93
  • Cause of death: ICD-9 3092A|3092B|3133A|3138B|3138C

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 F90-F98
Name in latin Perturbationes emotionales specialiter in pueritia incipientes

Case counts by codes

FinnGen case counts by registry codes:

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Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 46720 24547 22142
Only index persons 41611 22548 19063
Unadjusted period prevalence (%)
Whole population 0.66 0.70 0.62
Only index persons 0.78 0.83 0.73
Median age at first event (years)
Whole population 12.72 14.18 11.09
Only index persons 13.20 14.48 11.69

-FinnGen-

Key figures

All Female Male
Number of individuals 1860 1354 506
Unadjusted period prevalence (%) 0.46 0.53 0.25
Median age at first event (years) 15.26 15.76 13.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint KRA_PSY_CHILDEMOT_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_CHILDEMOT_EXMORE 2.109 [1.65, 2.7] < 0.001
Birth year 0.998 [0.99, 1.01] 0.599

During the follow-up period (1.1.1998 — 31.12.2019), 226 out of 19663 females with KRA_PSY_CHILDEMOT_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_CHILDEMOT_EXMORE 3.126 [2.39, 4.09] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 17868 males with KRA_PSY_CHILDEMOT_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_CHILDEMOT_EXMORE.

N-year risk Females Males
1 0.225% 0.442%
5 1.175% 3.543%
10 3.262% 9.172%
15 6.415% 16.462%
20 11.06% 26.722%

Relationships between endpoints

Index endpoint: KRA_PSY_CHILDEMOT_EXMORE – Emotional disorders starting during childhood or adolecense

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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