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Behavioural disorders

Endpoint Browser PheWeb

KRA_PSY_BEHAV_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F91
  • Hospital discharge: ICD-9 — 3120A|3123D|3138A
  • Hospital discharge: ICD-8 — 30899
  • Cause of death: ICD-10 — F91
  • Cause of death: ICD-9 — 3120A|3123D|3138A
  • Cause of death: ICD-8 — 30899

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 F90-F98
Name in latin Perturbationes modi se gerendi

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21707 6589 15089
Only index persons 19279 6060 13219
Unadjusted period prevalence (%)
Whole population 0.35 0.19 0.42
Only index persons 0.42 0.22 0.50
Median age at first event (years)
Whole population 12.68 14.11 12.05
Only index persons 13.20 14.28 12.70

-FinnGen-

Key figures

All Female Male
Number of individuals 736 368 368
Unadjusted period prevalence (%) 0.16 0.14 0.18
Median age at first event (years) 14.45 14.85 14.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_BEHAV_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_BEHAV_EXMORE 4.293 [2.76, 6.68] < 0.001
Birth year 0.995 [0.99, 1.0] 0.231

During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 5127 females with KRA_PSY_BEHAV_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_BEHAV_EXMORE 4.335 [2.95, 6.38] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 11422 males with KRA_PSY_BEHAV_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_BEHAV_EXMORE.

N-year risk Females Males
1 0.444% 0.848%
5 2.515% 4.814%
10 6.024% 11.507%
15 11.311% 20.535%
20 18.994% 31.626%

Relationships between endpoints

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Index endpoint: KRA_PSY_BEHAV_EXMORE – Behavioural disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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