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Pathological resorption of teeth

Endpoint Browser PheWeb

K11_RESORPTION

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K03.3
  • Hospital discharge: ICD-10 — K03.3
  • Hospital discharge: ICD-9 — 5214
  • Hospital discharge: ICD-8 — 5214
  • Cause of death: ICD-10 — K03.3
  • Cause of death: ICD-9 — 5214
  • Cause of death: ICD-8 — 5214

3 out of 7 registries used, show all original rules.

979

4. Check minimum number of events

None

979

5. Include endpoints

None

979

6. Filter based on genotype QC (FinnGen only)

939

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8173 4096 4025
Only index persons 7807 3965 3842
Unadjusted period prevalence (%)
Whole population 0.11 0.12 0.11
Only index persons 0.15 0.15 0.15
Median age at first event (years)
Whole population 43.95 45.06 42.96
Only index persons 45.30 45.97 44.61

-FinnGen-

Key figures

All Female Male
Number of individuals 939 526 413
Unadjusted period prevalence (%) 0.21 0.21 0.21
Median age at first event (years) 56.95 54.70 59.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_RESORPTION and mortality.

Females

Parameter HR [95% CI] p-value
K11_RESORPTION 1.033 [0.75, 1.43] 0.847
Birth year 0.994 [0.99, 1.0] 0.146

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 2965 females with K11_RESORPTION died.

Males

Parameter HR [95% CI] p-value
K11_RESORPTION 0.871 [0.65, 1.17] 0.356
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 2882 males with K11_RESORPTION died.

Mortality risk

Mortality risk for people of age

years, who have K11_RESORPTION.

N-year risk Females Males
1 0.108% 0.166%
5 0.522% 1.078%
10 1.429% 2.797%
15 2.818% 5.232%
20 4.904% 9.057%

Relationships between endpoints

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Index endpoint: K11_RESORPTION – Pathological resorption of teeth

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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