peritonitis: Inflammation of the peritoneum due to infection by bacteria or fungi. Causes include liver disease, perforation of the gastrointestinal tract or biliary tract, and peritoneal dialysis. Patients usually present with abdominal pain and tenderness, fever, chills, and nausea and vomiting. It is an emergency medical condition that requires prompt medical attention and treatment.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2224 |
4. Check minimum number of eventsNone |
2224 |
5. Include endpointsNone |
2224 |
6. Filter based on genotype QC (FinnGen only) |
2148 |
Control definitions (FinnGen only)
Control exclude
K11_PERITON
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K65-K67
Name in latin
Peritonitis
Acute peritonitis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 24750 | 11640 | 12708 |
| Only index persons | 16030 | 7658 | 8372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.35 | 0.33 | 0.36 |
| Only index persons | 0.30 | 0.28 | 0.32 |
| Median age at first event (years) | |||
| Whole population | 65.15 | 67.44 | 63.03 |
| Only index persons | 62.02 | 63.11 | 61.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2148 | 918 | 1230 |
| Unadjusted period prevalence (%) | 0.51 | 0.36 | 0.62 |
| Median age at first event (years) | 59.97 | 54.62 | 63.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_PERITONITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PERITONITIS | 3.216 [2.84, 3.65] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 2621 out of 5802 females with K11_PERITONITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PERITONITIS | 3.559 [3.15, 4.02] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 3308 out of 6832 males with K11_PERITONITIS died.
Mortality risk
Mortality risk for people of age
years, who have K11_PERITONITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.553% |
| 5 | 1.322% | 3.798% |
| 10 | 3.864% | 8.938% |
| 15 | 7.992% | 16.343% |
| 20 | 13.67% | 27.234% |
Relationships between endpoints
↥Index endpoint: K11_PERITONITIS – Acute peritonitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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