No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
257848 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
7381 |
4. Check minimum number of eventsNone |
7381 |
5. Include endpoints |
7770 |
6. Filter based on genotype QC (FinnGen only) |
7447 |
Control definitions (FinnGen only)
Control exclude
K11_ORAL
Control conditions
K11_DENTAL_OPER
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF10
Erosion of teeth, including avohilmo
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 56999 | 29441 | 27302 |
| Only index persons | 55268 | 28926 | 26342 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.80 | 0.84 | 0.76 |
| Only index persons | 1.04 | 1.06 | 1.01 |
| Median age at first event (years) | |||
| Whole population | 40.77 | 41.82 | 39.66 |
| Only index persons | 41.48 | 42.18 | 40.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7447 | 4686 | 2761 |
| Unadjusted period prevalence (%) | 1.67 | 1.84 | 1.39 |
| Median age at first event (years) | 50.25 | 47.33 | 55.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_EROSION_INCLAVO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_EROSION_INCLAVO | 0.832 [0.62, 1.13] | 0.233 |
| Birth year | 0.995 [0.99, 1.0] | 0.254 |
During the follow-up period (1.1.1998 — 31.12.2019), 236 out of 20595 females with K11_EROSION_INCLAVO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_EROSION_INCLAVO | 0.725 [0.53, 1.0] | 0.049 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 338 out of 18837 males with K11_EROSION_INCLAVO died.
Mortality risk
Mortality risk for people of age
years, who have K11_EROSION_INCLAVO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.08% | 0.117% |
| 5 | 0.455% | 0.795% |
| 10 | 1.232% | 2.013% |
| 15 | 2.276% | 3.949% |
| 20 | 4.232% | 6.821% |
Relationships between endpoints
↥Index endpoint: K11_EROSION_INCLAVO – Erosion of teeth, including avohilmo
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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