No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
9939 |
4. Check minimum number of eventsNone |
9939 |
5. Include endpointsNone |
9939 |
6. Filter based on genotype QC (FinnGen only) |
9446 |
Control definitions (FinnGen only)
Control exclude
K11_ORAL
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Dentinal caries
based on the number of shared cases.
Similar with more cases:
- Dental caries
- Diseases of oral cavity, salivary glands and jaws
- Dental caries 3
- Dental caries 1
- Dental caries, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 94695 | 40425 | 53762 |
| Only index persons | 82764 | 35639 | 47125 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.35 | 1.16 | 1.50 |
| Only index persons | 1.59 | 1.31 | 1.80 |
| Median age at first event (years) | |||
| Whole population | 40.63 | 38.60 | 42.14 |
| Only index persons | 43.50 | 42.10 | 44.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9446 | 4278 | 5168 |
| Unadjusted period prevalence (%) | 2.18 | 1.68 | 2.60 |
| Median age at first event (years) | 55.01 | 51.81 | 57.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_CARIES_DENTIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CARIES_DENTIN | 3.677 [3.23, 4.18] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.176 |
During the follow-up period (1.1.1998 — 31.12.2019), 5489 out of 32642 females with K11_CARIES_DENTIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CARIES_DENTIN | 3.79 [3.33, 4.31] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 9680 out of 44019 males with K11_CARIES_DENTIN died.
Mortality risk
Mortality risk for people of age
years, who have K11_CARIES_DENTIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.324% | 0.709% |
| 5 | 1.811% | 4.164% |
| 10 | 5.004% | 9.542% |
| 15 | 9.26% | 17.81% |
| 20 | 16.651% | 29.144% |
Relationships between endpoints
↥Index endpoint: K11_CARIES_DENTIN – Dentinal caries
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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