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Excessive attrition of teeth

Endpoint Browser PheWeb

K11_ATTRITION

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • K11_DENTAL_OPER
257848

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K03.0
  • Hospital discharge: ICD-10 — K03.0
  • Hospital discharge: ICD-9 — 5211
  • Hospital discharge: ICD-8 — 5211
  • Cause of death: ICD-10 — K03.0
  • Cause of death: ICD-9 — 5211
  • Cause of death: ICD-8 — 5211

3 out of 7 registries used, show all original rules.

19408

4. Check minimum number of events

None

19408

5. Include endpoints

None

19408

6. Filter based on genotype QC (FinnGen only)

18610

Control definitions (FinnGen only)

Control exclude K11_ORAL
Control conditions K11_DENTAL_OPER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 121956 67164 54240
Only index persons 118875 66186 52689
Unadjusted period prevalence (%)
Whole population 1.74 1.92 1.52
Only index persons 2.25 2.43 2.01
Median age at first event (years)
Whole population 49.42 48.78 50.35
Only index persons 49.96 49.11 51.02

-FinnGen-

Key figures

All Female Male
Number of individuals 18610 11713 6897
Unadjusted period prevalence (%) 4.18 4.60 3.46
Median age at first event (years) 55.94 53.32 60.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_ATTRITION and mortality.

Females

Parameter HR [95% CI] p-value
K11_ATTRITION 0.675 [0.5, 0.9] 0.008
Birth year 0.993 [0.98, 1.0] 0.098

During the follow-up period (1.1.1998 — 31.12.2019), 566 out of 44496 females with K11_ATTRITION died.

Males

Parameter HR [95% CI] p-value
K11_ATTRITION 0.733 [0.57, 0.94] 0.015
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 996 out of 35933 males with K11_ATTRITION died.

Mortality risk

Mortality risk for people of age

years, who have K11_ATTRITION.

N-year risk Females Males
1 0.06% 0.136%
5 0.366% 0.785%
10 0.92% 2.087%
15 1.697% 4.142%
20 3.04% 6.849%

Relationships between endpoints

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Index endpoint: K11_ATTRITION – Excessive attrition of teeth

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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