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Abrasion of teeth

Endpoint Browser PheWeb

K11_ABRASION

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • K11_DENTAL_OPER
257848

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K03.1
  • Hospital discharge: ICD-10 — K03.1
  • Hospital discharge: ICD-9 — 5212
  • Hospital discharge: ICD-8 — 5212
  • Cause of death: ICD-10 — K03.1
  • Cause of death: ICD-9 — 5212
  • Cause of death: ICD-8 — 5212

3 out of 7 registries used, show all original rules.

11128

4. Check minimum number of events

None

11128

5. Include endpoints

None

11128

6. Filter based on genotype QC (FinnGen only)

10660

Control definitions (FinnGen only)

Control exclude K11_ORAL
Control conditions K11_DENTAL_OPER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 69217 45162 23680
Only index persons 68331 44903 23428
Unadjusted period prevalence (%)
Whole population 1.07 1.29 0.66
Only index persons 1.39 1.65 0.89
Median age at first event (years)
Whole population 56.92 56.92 57.21
Only index persons 57.12 56.99 57.36

-FinnGen-

Key figures

All Female Male
Number of individuals 10660 7460 3200
Unadjusted period prevalence (%) 2.53 2.93 1.61
Median age at first event (years) 60.18 58.76 63.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_ABRASION and mortality.

Females

Parameter HR [95% CI] p-value
K11_ABRASION 0.532 [0.42, 0.68] < 0.001
Birth year 0.996 [0.99, 1.0] 0.327

During the follow-up period (1.1.1998 — 31.12.2019), 471 out of 33305 females with K11_ABRASION died.

Males

Parameter HR [95% CI] p-value
K11_ABRASION 0.56 [0.44, 0.72] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 497 out of 17666 males with K11_ABRASION died.

Mortality risk

Mortality risk for people of age

years, who have K11_ABRASION.

N-year risk Females Males
1 0.05% 0.108%
5 0.272% 0.665%
10 0.792% 1.713%
15 1.487% 3.199%
20 2.795% 5.456%

Relationships between endpoints

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Index endpoint: K11_ABRASION – Abrasion of teeth

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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