Other diseases of the respiratory system

J10_RESPOTHER

respiratory system disease: A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

6798

4. Check minimum number of events

None

6798

5. Include endpoints

7890

6. Filter based on genotype QC (FinnGen only)

7624

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 77564 32394 43783
Only index persons 53570 24149 29421
Unadjusted period prevalence (%)
Whole population 1.10 0.93 1.22
Only index persons 1.02 0.89 1.12
Median age at first event (years)
Whole population 66.75 67.54 66.14
Only index persons 66.54 67.19 66.01

-FinnGen-

Key figures

All Female Male
Number of individuals 7624 2795 4829
Unadjusted period prevalence (%) 1.94 1.10 2.43
Median age at first event (years) 66.75 63.47 68.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_RESPOTHER and mortality.

Females

Parameter HR [95% CI] p-value
J10_RESPOTHER 5.137 [4.57, 5.78] < 0.001
Birth year 0.998 [0.99, 1.01] 0.514

During the follow-up period (1.1.1998 — 31.12.2019), 9925 out of 18310 females with J10_RESPOTHER died.

Males

Parameter HR [95% CI] p-value
J10_RESPOTHER 4.612 [4.05, 5.26] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 14174 out of 24103 males with J10_RESPOTHER died.

Mortality risk

Mortality risk for people of age

years, who have J10_RESPOTHER.

N-year risk Females Males
1 0.4% 0.689%
5 3.089% 4.082%
10 7.873% 10.889%
15 14.345% 20.729%
20 23.448% 31.83%

Relationships between endpoints

Index endpoint: J10_RESPOTHER – Other diseases of the respiratory system

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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