respiratory system disease: A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
6798 |
4. Check minimum number of eventsNone |
6798 |
5. Include endpoints |
7890 |
6. Filter based on genotype QC (FinnGen only) |
7624 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Similar endpoints
↥List of similar endpoints to Other diseases of the respiratory system based on the number of shared cases.
Similar with more cases:
- Other respiratory disorders and diseases
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 77564 | 32394 | 43783 |
Only index persons | 53570 | 24149 | 29421 |
Unadjusted period prevalence (%) | |||
Whole population | 1.10 | 0.93 | 1.22 |
Only index persons | 1.02 | 0.89 | 1.12 |
Median age at first event (years) | |||
Whole population | 66.75 | 67.54 | 66.14 |
Only index persons | 66.54 | 67.19 | 66.01 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 7624 | 2795 | 4829 |
Unadjusted period prevalence (%) | 1.94 | 1.10 | 2.43 |
Median age at first event (years) | 66.75 | 63.47 | 68.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_RESPOTHER and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_RESPOTHER | 5.137 [4.57, 5.78] | < 0.001 |
Birth year | 0.998 [0.99, 1.01] | 0.514 |
During the follow-up period (1.1.1998 — 31.12.2019), 9925 out of 18310 females with J10_RESPOTHER died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_RESPOTHER | 4.612 [4.05, 5.26] | < 0.001 |
Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 14174 out of 24103 males with J10_RESPOTHER died.
Mortality risk
Mortality risk for people of age
years, who have J10_RESPOTHER.N-year risk | Females | Males |
---|---|---|
1 | 0.4% | 0.689% |
5 | 3.089% | 4.082% |
10 | 7.873% | 10.889% |
15 | 14.345% | 20.729% |
20 | 23.448% | 31.83% |
Relationships between endpoints
↥Index endpoint: J10_RESPOTHER – Other diseases of the respiratory system
GWS hits: 1