No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
408 |
4. Check minimum number of eventsNone |
408 |
5. Include endpointsNone |
408 |
6. Filter based on genotype QC (FinnGen only) |
387 |
Control definitions (FinnGen only)
Control exclude
J10_INTERSTITIUM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
J80-J84
Name in latin
Syndroma dyspnoicum adultorum
Similar endpoints
↥List of similar endpoints to
Adult respiratory distress syndrome
based on the number of shared cases.
Similar with more cases:
- Other respiratory diseases principally affecting the interstitium
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4454 | 1675 | 2699 |
| Only index persons | 2675 | 1057 | 1618 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.05 | 0.08 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 64.11 | 63.05 | 64.59 |
| Only index persons | 63.57 | 61.33 | 65.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 387 | 130 | 257 |
| Unadjusted period prevalence (%) | 0.10 | 0.05 | 0.13 |
| Median age at first event (years) | 62.85 | 54.23 | 67.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_ARDS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ARDS | 4.114 [2.99, 5.67] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 380 out of 840 females with J10_ARDS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ARDS | 3.869 [3.11, 4.82] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 581 out of 1115 males with J10_ARDS died.
Mortality risk
Mortality risk for people of age
years, who have J10_ARDS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.343% | 0.847% |
| 5 | 2.574% | 4.935% |
| 10 | 6.118% | 11.15% |
| 15 | 11.445% | 19.998% |
| 20 | 18.726% | 31.948% |
Relationships between endpoints
↥Index endpoint: J10_ARDS – Adult respiratory distress syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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