brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
302 |
4. Check minimum number of eventsNone |
302 |
5. Include endpointsNone |
302 |
6. Filter based on genotype QC (FinnGen only) |
285 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I67
Name in latin
Thrombosis non pyogenes systematis venosi intracranialis
Similar endpoints
↥List of similar endpoints to
Nonpyogenic thrombosis of intracranial venous system
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1945 | 1146 | 787 |
| Only index persons | 1787 | 1081 | 706 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 47.77 | 44.15 | 53.10 |
| Only index persons | 47.16 | 43.52 | 52.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 285 | 183 | 102 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 49.26 | 44.63 | 57.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBICV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBICV | 2.151 [1.58, 2.92] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 100 out of 916 females with I9_THROMBICV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBICV | 2.538 [1.86, 3.46] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 619 males with I9_THROMBICV died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBICV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.224% | 0.476% |
| 5 | 1.437% | 3.118% |
| 10 | 3.209% | 7.444% |
| 15 | 5.841% | 13.79% |
| 20 | 10.125% | 22.083% |
Relationships between endpoints
↥Index endpoint: I9_THROMBICV – Nonpyogenic thrombosis of intracranial venous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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