thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
120 |
4. Check minimum number of eventsNone |
120 |
5. Include endpointsNone |
120 |
6. Filter based on genotype QC (FinnGen only) |
115 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I73
Name in latin
Tromboangi(i)tis obliterans (Bürger)
Similar endpoints
↥List of similar endpoints to
Thromboangiitis obliterans
based on the number of shared cases.
Similar with more cases:
- Other peripheral vascular diseases
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1319 | 389 | 900 |
| Only index persons | 869 | 322 | 547 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.03 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.80 | 53.06 | 52.44 |
| Only index persons | 51.00 | 51.70 | 50.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 115 | 41 | 74 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 49.48 | 46.58 | 51.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 2.288 [1.72, 3.04] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.357 |
During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 256 females with I9_THROMBANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 1.982 [1.58, 2.48] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 390 males with I9_THROMBANG died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.265% | 0.289% |
| 5 | 1.479% | 2.21% |
| 10 | 3.389% | 5.427% |
| 15 | 6.828% | 9.841% |
| 20 | 11.912% | 16.326% |
Relationships between endpoints
↥Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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