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Other peripheral vascular diseases

DOID EFO Endpoint Browser PheWeb

I9_OTHPER

peripheral arterial disease: A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I73
  • Hospital discharge: ICD-9 — 443
  • Hospital discharge: ICD-8 — 443
  • Cause of death: ICD-10 — I73
  • Cause of death: ICD-9 — 443
  • Cause of death: ICD-8 — 443

2 out of 7 registries used, show all original rules.

2870

4. Check minimum number of events

None

2870

5. Include endpoints

2870

6. Filter based on genotype QC (FinnGen only)

2793

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I70-I79
Name in latin Alii morbi vasorum periphericorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 22570 12619 9640
Only index persons 17684 11139 6545
Unadjusted period prevalence (%)
Whole population 0.32 0.36 0.27
Only index persons 0.35 0.41 0.25
Median age at first event (years)
Whole population 50.54 45.53 56.80
Only index persons 47.80 43.90 54.43

-FinnGen-

Key figures

All Female Male
Number of individuals 2793 1757 1036
Unadjusted period prevalence (%) 0.63 0.69 0.52
Median age at first event (years) 49.86 45.32 57.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_OTHPER and mortality.

Females

Parameter HR [95% CI] p-value
I9_OTHPER 1.7 [1.52, 1.91] < 0.001
Birth year 0.991 [0.98, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 1192 out of 7354 females with I9_OTHPER died.

Males

Parameter HR [95% CI] p-value
I9_OTHPER 1.81 [1.64, 2.0] < 0.001
Birth year 0.993 [0.98, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 1800 out of 5294 males with I9_OTHPER died.

Mortality risk

Mortality risk for people of age

years, who have I9_OTHPER.

N-year risk Females Males
1 0.137% 0.308%
5 0.916% 2.373%
10 2.318% 6.072%
15 4.252% 11.376%
20 7.267% 19.122%

Relationships between endpoints

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Index endpoint: I9_OTHPER – Other peripheral vascular diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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