intracranial embolism: Blocking of a blood vessel in the skull by an embolus which can be a blood clot (thrombus) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with heart diseases. Other non-cardiac sources of emboli are usually associated with vascular diseases.
Occlusion and stenosis of arteries, not leading to stroke
DOID EFO Endpoint Browser PheWeb
I9_STENOSIS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
506 |
4. Check minimum number of eventsNone |
506 |
5. Include endpointsNone |
506 |
6. Filter based on genotype QC (FinnGen only) |
483 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I60-I69
Name in latin
Occlusio sive stenosis arteriarum cerebralium sine infarctu
Similar endpoints
↥List of similar endpoints to
Occlusion and stenosis of arteries, not leading to stroke
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7018 | 2849 | 3990 |
| Only index persons | 3710 | 1691 | 2019 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.08 | 0.11 |
| Only index persons | 0.07 | 0.06 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 67.81 | 70.75 | 65.76 |
| Only index persons | 65.92 | 68.76 | 63.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 483 | 151 | 332 |
| Unadjusted period prevalence (%) | 0.13 | 0.06 | 0.17 |
| Median age at first event (years) | 62.52 | 62.31 | 62.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_STENOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.749 [1.52, 2.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 656 out of 1237 females with I9_STENOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.811 [1.56, 2.1] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 719 out of 1395 males with I9_STENOSIS died.
Mortality risk
Mortality risk for people of age
years, who have I9_STENOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.308% |
| 5 | 1.036% | 2.107% |
| 10 | 2.553% | 5.306% |
| 15 | 4.843% | 9.863% |
| 20 | 8.837% | 16.834% |
Relationships between endpoints
↥Index endpoint: I9_STENOSIS – Occlusion and stenosis of arteries, not leading to stroke
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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