brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
964 |
4. Check minimum number of eventsNone |
964 |
5. Include endpointsNone |
964 |
6. Filter based on genotype QC (FinnGen only) |
930 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I67
Name in latin
Leucoencephalopathia vascularis progressiva
Similar endpoints
↥List of similar endpoints to
Progressive vascular leukoencephalopathy
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8396 | 4988 | 3358 |
| Only index persons | 7636 | 4604 | 3032 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.14 | 0.09 |
| Only index persons | 0.15 | 0.17 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 80.45 | 81.63 | 78.75 |
| Only index persons | 80.80 | 81.89 | 79.13 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 930 | 474 | 456 |
| Unadjusted period prevalence (%) | 0.21 | 0.19 | 0.23 |
| Median age at first event (years) | 79.46 | 79.75 | 79.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_PROGVASC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_PROGVASC | 1.801 [1.51, 2.14] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.614 |
During the follow-up period (1.1.1998 — 31.12.2019), 1426 out of 3641 females with I9_PROGVASC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_PROGVASC | 2.237 [1.78, 2.82] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1110 out of 2445 males with I9_PROGVASC died.
Mortality risk
Mortality risk for people of age
years, who have I9_PROGVASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.372% |
| 5 | 1.113% | 2.372% |
| 10 | 2.898% | 6.012% |
| 15 | 5.374% | 11.12% |
| 20 | 9.441% | 18.33% |
Relationships between endpoints
↥Index endpoint: I9_PROGVASC – Progressive vascular leukoencephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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