hypertensive encephalopathy: Encephalopathy resulting from hypertension.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
114 |
4. Check minimum number of eventsNone |
114 |
5. Include endpointsNone |
114 |
6. Filter based on genotype QC (FinnGen only) |
113 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I67
Name in latin
Encephalopathia hypertensiva
Similar endpoints
↥List of similar endpoints to
Hypertensive encephalopathy
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Hypertension
- Hypertensive diseases (excluding secondary)
- Hypertensive diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1060 | 561 | 482 |
| Only index persons | 823 | 460 | 363 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 67.18 | 71.76 | 61.86 |
| Only index persons | 66.77 | 72.24 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 113 | 58 | 55 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 66.63 | 67.89 | 65.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPERTENC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTENC | 1.734 [1.28, 2.34] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.144 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 379 females with I9_HYPERTENC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTENC | 1.693 [1.05, 2.72] | 0.03 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 273 males with I9_HYPERTENC died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPERTENC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.273% |
| 5 | 1.208% | 1.923% |
| 10 | 2.592% | 4.794% |
| 15 | 4.882% | 8.678% |
| 20 | 8.622% | 14.586% |
Relationships between endpoints
↥Index endpoint: I9_HYPERTENC – Hypertensive encephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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