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Coronary atherosclerosis

DOID EFO Endpoint Browser PheWeb

I9_CORATHER

heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I24, I25, T82.2, Z95.1
  • Hospital discharge: ICD-9 — 414|9960A
  • Hospital discharge: ICD-8 — 414
  • Hospital discharge: excluded ICD-10 — I25.3
  • Cause of death: ICD-10 — I24, I25, T82.2, Z95.1
  • Cause of death: ICD-9 — 414|9960A
  • Cause of death: ICD-8 — 414
  • Cause of death: excluded ICD-10 — I25.3

2 out of 7 registries used, show all original rules.

58688

4. Check minimum number of events

None

58688

5. Include endpoints

None

58688

6. Filter based on genotype QC (FinnGen only)

56685

Control definitions (FinnGen only)

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 657584 279386 367876
Only index persons 436363 184909 251454
Unadjusted period prevalence (%)
Whole population 9.32 8.00 10.28
Only index persons 8.41 6.80 9.60
Median age at first event (years)
Whole population 72.88 77.44 69.41
Only index persons 71.32 76.17 67.74

-FinnGen-

Key figures

All Female Male
Number of individuals 56685 17561 39124
Unadjusted period prevalence (%) 15.70 6.90 19.65
Median age at first event (years) 68.41 69.71 67.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_CORATHER and mortality.

Females

Parameter HR [95% CI] p-value
I9_CORATHER 1.931 [1.79, 2.09] < 0.001
Birth year 0.987 [0.98, 1.0] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 89079 out of 166934 females with I9_CORATHER died.

Males

Parameter HR [95% CI] p-value
I9_CORATHER 1.649 [1.53, 1.78] < 0.001
Birth year 0.987 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 96810 out of 219429 males with I9_CORATHER died.

Mortality risk

Mortality risk for people of age

years, who have I9_CORATHER.

N-year risk Females Males
1 0.111% 0.214%
5 0.798% 1.488%
10 2.045% 3.61%
15 3.793% 7.058%
20 6.181% 11.9%

Relationships between endpoints

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Index endpoint: I9_CORATHER – Coronary atherosclerosis

GWS hits: 95

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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