Cerebral arteritis

I9_CEREBRART

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

86

4. Check minimum number of events

None

86

5. Include endpoints

None

86

6. Filter based on genotype QC (FinnGen only)

83

Control definitions (FinnGen only)

Control exclude I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 614 387 221
Only index persons 486 311 175
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 53.20 52.39 54.98
Only index persons 49.65 48.58 51.56

-FinnGen-

Key figures

All Female Male
Number of individuals 83 53 30
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 47.12 45.42 50.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint I9_CEREBRART and mortality.

Females

Parameter HR [95% CI] p-value
I9_CEREBRART 2.464 [1.74, 3.48] < 0.001
Birth year 0.994 [0.99, 1.0] 0.153

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 288 females with I9_CEREBRART died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have I9_CEREBRART.

N-year risk Females Males
1 0.188% No data
5 1.119% No data
10 3.367% No data
15 6.757% No data
20 11.596% No data

Relationships between endpoints

Index endpoint: I9_CEREBRART – Cerebral arteritis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data