sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4477 |
4. Check minimum number of eventsNone |
4477 |
5. Include endpointsNone |
4477 |
6. Filter based on genotype QC (FinnGen only) |
4292 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Mixed conductive and sensorineural hearing loss
based on the number of shared cases.
Similar with more cases:
- Conductive and sensorineural hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 36727 | 19869 | 16663 |
| Only index persons | 34045 | 18719 | 15326 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.52 | 0.57 | 0.47 |
| Only index persons | 0.64 | 0.69 | 0.59 |
| Median age at first event (years) | |||
| Whole population | 62.97 | 63.35 | 62.45 |
| Only index persons | 62.24 | 62.65 | 61.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4292 | 2279 | 2013 |
| Unadjusted period prevalence (%) | 0.95 | 0.90 | 1.01 |
| Median age at first event (years) | 61.52 | 59.35 | 63.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_MIX_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_MIX_NAS | 0.993 [0.92, 1.07] | 0.846 |
| Birth year | 0.994 [0.99, 1.0] | 0.124 |
During the follow-up period (1.1.1998 — 31.12.2019), 4413 out of 18401 females with H8_HL_MIX_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_MIX_NAS | 0.992 [0.91, 1.08] | 0.842 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 4113 out of 15201 males with H8_HL_MIX_NAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_MIX_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.181% |
| 5 | 0.554% | 1.226% |
| 10 | 1.44% | 3.036% |
| 15 | 2.885% | 5.615% |
| 20 | 4.912% | 9.624% |
Relationships between endpoints
↥Index endpoint: H8_HL_MIX_NAS – Mixed conductive and sensorineural hearing loss
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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