No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3083 |
4. Check minimum number of eventsNone |
3083 |
5. Include endpointsNone |
3083 |
6. Filter based on genotype QC (FinnGen only) |
2918 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Conductive hearing loss, unspecified
based on the number of shared cases.
Similar with more cases:
- Conductive and sensorineural hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29372 | 15605 | 13612 |
| Only index persons | 27163 | 14637 | 12526 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.41 | 0.45 | 0.38 |
| Only index persons | 0.51 | 0.54 | 0.48 |
| Median age at first event (years) | |||
| Whole population | 47.02 | 48.69 | 45.13 |
| Only index persons | 47.49 | 49.19 | 45.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2918 | 1681 | 1237 |
| Unadjusted period prevalence (%) | 0.64 | 0.66 | 0.62 |
| Median age at first event (years) | 53.35 | 51.13 | 56.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_CON_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_CON_NAS | 0.969 [0.88, 1.07] | 0.529 |
| Birth year | 0.997 [0.99, 1.01] | 0.503 |
During the follow-up period (1.1.1998 — 31.12.2019), 1734 out of 14162 females with H8_HL_CON_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_CON_NAS | 0.964 [0.86, 1.07] | 0.505 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1735 out of 12076 males with H8_HL_CON_NAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_CON_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.181% |
| 5 | 0.629% | 0.973% |
| 10 | 1.507% | 2.45% |
| 15 | 2.841% | 4.827% |
| 20 | 5.133% | 8.084% |
Relationships between endpoints
↥Index endpoint: H8_HL_CON_NAS – Conductive hearing loss, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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