pterygium: A wedge-shaped fibrovascular lesion arising from the bulbar conjunctiva and extending to the cornea. It is caused by chronic exposure to solar ultraviolet radiation, heat, and dust. It may cause severe vision loss. Studies have linked pterygium to neoplastic proliferation and suggest that it may be a stem cell disorder.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
924 |
4. Check minimum number of eventsNone |
924 |
5. Include endpointsNone |
924 |
6. Filter based on genotype QC (FinnGen only) |
842 |
Control definitions (FinnGen only)
Control exclude
H7_CONJUNCTIVA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H11
Name in latin
Pterygium
Similar endpoints
↥List of similar endpoints to
Pterygium
based on the number of shared cases.
Similar with more cases:
- Other disorders of conjunctiva
- Disorders of conjunctiva
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10019 | 3736 | 6008 |
| Only index persons | 8003 | 3281 | 4722 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.11 | 0.17 |
| Only index persons | 0.16 | 0.12 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 59.38 | 58.25 | 60.83 |
| Only index persons | 58.52 | 56.95 | 59.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 842 | 310 | 532 |
| Unadjusted period prevalence (%) | 0.21 | 0.12 | 0.27 |
| Median age at first event (years) | 61.03 | 56.99 | 63.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PTERYGIUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTERYGIUM | 0.801 [0.69, 0.92] | 0.002 |
| Birth year | 0.993 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 2393 females with H7_PTERYGIUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PTERYGIUM | 0.781 [0.7, 0.87] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 750 out of 3406 males with H7_PTERYGIUM died.
Mortality risk
Mortality risk for people of age
years, who have H7_PTERYGIUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.067% | 0.156% |
| 5 | 0.458% | 1.033% |
| 10 | 1.213% | 2.673% |
| 15 | 2.145% | 5.331% |
| 20 | 3.639% | 9.071% |
Relationships between endpoints
↥Index endpoint: H7_PTERYGIUM – Pterygium
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data