Episcleritis

H7_EPISCLERITIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H15.1
  • Hospital discharge: ICD-8 36903
  • Cause of death: ICD-10 H15.1
  • Cause of death: ICD-8 36903

2 out of 7 registries used, show all original rules.

1805

4. Check minimum number of events

None

1805

5. Include endpoints

None

1805

6. Filter based on genotype QC (FinnGen only)

1744

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H15
Name in latin Episcleritis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12330 7764 4495
Only index persons 11967 7599 4368
Unadjusted period prevalence (%)
Whole population 0.19 0.22 0.13
Only index persons 0.24 0.28 0.17
Median age at first event (years)
Whole population 46.37 47.31 44.90
Only index persons 46.22 47.12 44.66

-FinnGen-

Key figures

All Female Male
Number of individuals 1744 1229 515
Unadjusted period prevalence (%) 0.42 0.48 0.26
Median age at first event (years) 48.64 47.57 51.18

-FinRegistry-

Age distribution of first events

01020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8k2.0k2.2k2.4k2.6k2.8kAgeIndividuals

-FinnGen-

Age distribution of first events

0102030405060708090050100150200250300350400AgeIndividuals

-FinRegistry-

Year distribution of first events

197519801985199019952000200520102015202020220.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8k2.0k2.2k2.4k2.6k2.8kYearIndividuals

-FinnGen-

Year distribution of first events

19701980200020052010201520202023050100150200250300350400YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.0AgeProbability of first incidence (%)

Mortality – FinRegistry

Association

Association between endpoint H7_EPISCLERITIS and mortality.

Females

Parameter HR [95% CI] p-value
H7_EPISCLERITIS 0.976 [0.86, 1.11] 0.716
Birth year 0.995 [0.99, 1.0] 0.202

During the follow-up period (1.1.1998 — 31.12.2019), 401 out of 6850 females with H7_EPISCLERITIS died.

Males

Parameter HR [95% CI] p-value
H7_EPISCLERITIS 0.891 [0.78, 1.02] 0.088
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 333 out of 3989 males with H7_EPISCLERITIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_EPISCLERITIS.

N-year risk Females Males
1 0.079% 0.105%
5 0.549% 0.867%
10 1.368% 2.199%
15 2.618% 4.184%
20 4.691% 7.167%

Relationships between endpoints

Index endpoint: H7_EPISCLERITIS – Episcleritis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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