pinguecula: A yellowish thickened lesion on the conjunctiva near the cornea representing a benign degenerative change in the conjunctiva caused by the leakage and deposition of certain blood proteins through the permeable capillaries near the limbus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
702 |
4. Check minimum number of eventsNone |
702 |
5. Include endpointsNone |
702 |
6. Filter based on genotype QC (FinnGen only) |
671 |
Control definitions (FinnGen only)
Control exclude
H7_CONJUNCTIVA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H11
Name in latin
Degenerationes et deposita conjunctivae
Similar endpoints
↥List of similar endpoints to
conjunctival degenerations and deposits
based on the number of shared cases.
Similar with more cases:
- Other disorders of conjunctiva
- Disorders of conjunctiva
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5600 | 3529 | 2024 |
| Only index persons | 5007 | 3200 | 1807 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 53.72 | 53.94 | 53.55 |
| Only index persons | 52.74 | 52.84 | 52.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 671 | 429 | 242 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.12 |
| Median age at first event (years) | 53.10 | 51.32 | 56.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_CONJUNCTDEGDEPOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONJUNCTDEGDEPOT | 1.186 [1.08, 1.3] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.208 |
During the follow-up period (1.1.1998 — 31.12.2019), 778 out of 3296 females with H7_CONJUNCTDEGDEPOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CONJUNCTDEGDEPOT | 1.055 [0.94, 1.19] | 0.384 |
| Birth year | 0.986 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 474 out of 1823 males with H7_CONJUNCTDEGDEPOT died.
Mortality risk
Mortality risk for people of age
years, who have H7_CONJUNCTDEGDEPOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.14% | 0.185% |
| 5 | 0.716% | 1.11% |
| 10 | 1.788% | 3.068% |
| 15 | 3.429% | 5.735% |
| 20 | 5.936% | 9.686% |
Relationships between endpoints
↥Index endpoint: H7_CONJUNCTDEGDEPOT – conjunctival degenerations and deposits
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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