conjunctival haemorrhage

H7_CONJUHAEMOR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H11.3
  • Cause of death: ICD-10 H11.3

2 out of 7 registries used, show all original rules.

2449

4. Check minimum number of events

None

2449

5. Include endpoints

None

2449

6. Filter based on genotype QC (FinnGen only)

2369

Control definitions (FinnGen only)

Control exclude H7_CONJUNCTIVA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H11
Name in latin Haemorrhagia conjunctivae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17760 9353 8327
Only index persons 16686 8922 7764
Unadjusted period prevalence (%)
Whole population 0.25 0.27 0.23
Only index persons 0.31 0.33 0.30
Median age at first event (years)
Whole population 63.98 65.11 62.79
Only index persons 64.10 65.11 62.94

-FinnGen-

Key figures

All Female Male
Number of individuals 2369 1309 1060
Unadjusted period prevalence (%) 0.52 0.51 0.53
Median age at first event (years) 64.97 63.43 66.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_CONJUHAEMOR and mortality.

Females

Parameter HR [95% CI] p-value
H7_CONJUHAEMOR 1.172 [1.04, 1.32] 0.01
Birth year 0.993 [0.98, 1.0] 0.107

During the follow-up period (1.1.1998 — 31.12.2019), 1283 out of 7818 females with H7_CONJUHAEMOR died.

Males

Parameter HR [95% CI] p-value
H7_CONJUHAEMOR 1.187 [1.05, 1.35] 0.008
Birth year 0.991 [0.98, 1.0] 0.054

During the follow-up period (1.1.1998 — 31.12.2019), 1396 out of 6926 males with H7_CONJUHAEMOR died.

Mortality risk

Mortality risk for people of age

years, who have H7_CONJUHAEMOR.

N-year risk Females Males
1 0.108% 0.274%
5 0.597% 1.553%
10 1.715% 3.803%
15 3.438% 7.197%
20 5.735% 12.1%

Relationships between endpoints

Index endpoint: H7_CONJUHAEMOR – conjunctival haemorrhage

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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