Gestational diabetes is a type of diabetes that can develop during pregnancy in women who don't already have diabetes
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
17740 |
4. Check minimum number of eventsNone |
17740 |
5. Include endpointsNone |
17740 |
6. Filter based on genotype QC (FinnGen only) |
16802 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
O24
Name in latin
Diabetes mellitus in gravidate apparens
Similar endpoints
↥List of similar endpoints to
Gestational diabetes (for exclusion)
based on the number of shared cases.
Similar with more cases:
- Other maternal disorders predominantly related to pregnancy
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 124013 | 124013 | - |
| Only index persons | 122991 | 122991 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.55 | 3.55 | - |
| Only index persons | 4.52 | 4.52 | - |
| Median age at first event (years) | |||
| Whole population | - | 31.54 | - |
| Only index persons | - | 31.53 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16802 | 16802 | - |
| Unadjusted period prevalence (%) | 6.60 | 6.60 | - |
| Median age at first event (years) | 31.71 | 31.71 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint GEST_DIABETES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GEST_DIABETES | 0.715 [0.62, 0.83] | < 0.001 |
| Birth year | 1.001 [0.99, 1.01] | 0.871 |
During the follow-up period (1.1.1998 — 31.12.2019), 581 out of 97250 females with GEST_DIABETES died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have GEST_DIABETES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | No data |
| 5 | 0.43% | No data |
| 10 | 1.234% | No data |
| 15 | 2.497% | No data |
| 20 | 4.487% | No data |
Relationships between endpoints
↥Index endpoint: GEST_DIABETES – Gestational diabetes (for exclusion)
GWS hits: 17
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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