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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Toxic myoneural disorders

G6_TOXMYONEU

Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G70.1
  • Hospital discharge: ICD-9 3582
  • Cause of death: ICD-10 G70.1
  • Cause of death: ICD-9 3582

2 out of 7 registries used, show all original rules.

18

4. Check minimum number of events

None

18

5. Include endpoints

None

18

6. Filter based on genotype QC (FinnGen only)

18

Control definitions (FinnGen only)

Control exclude G6_MYONEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G70
Name in latin Morbositates myoneurales toxicae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 149 85 63
Only index persons 128 73 55
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 58.80 58.36 59.58
Only index persons 57.32 58.36 55.94

-FinnGen-

Key figures

All Female Male
Number of individuals 18 13 5
Unadjusted period prevalence (%) 0.00 0.01 0.00
Median age at first event (years) 54.43 53.85 55.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint G6_TOXMYONEU and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_TOXMYONEU.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: G6_TOXMYONEU – Toxic myoneural disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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