Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
525 |
4. Check minimum number of eventsNone |
525 |
5. Include endpointsNone |
525 |
6. Filter based on genotype QC (FinnGen only) |
504 |
Control definitions (FinnGen only)
Control exclude
G6_MYONEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G70
Similar endpoints
↥List of similar endpoints to
Myasthenia gravis
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
- Neurological diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3518 | 1791 | 1681 |
| Only index persons | 2942 | 1550 | 1392 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 56.01 | 50.07 | 62.40 |
| Only index persons | 54.55 | 48.24 | 61.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 504 | 266 | 238 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 54.28 | 47.30 | 62.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_MYASTHENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYASTHENIA | 1.455 [1.19, 1.78] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 993 females with G6_MYASTHENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYASTHENIA | 1.196 [1.01, 1.42] | 0.04 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 1043 males with G6_MYASTHENIA died.
Mortality risk
Mortality risk for people of age
years, who have G6_MYASTHENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.116% | 0.157% |
| 5 | 0.643% | 1.359% |
| 10 | 1.895% | 3.372% |
| 15 | 3.606% | 6.583% |
| 20 | 6.362% | 11.147% |
Relationships between endpoints
↥Index endpoint: G6_MYASTHENIA – Myasthenia gravis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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