No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
4001 |
4. Check minimum number of eventsNone |
4001 |
5. Include endpointsNone |
4001 |
6. Filter based on genotype QC (FinnGen only) |
3850 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF10
Similar endpoints
↥List of similar endpoints to
Restless leg syndrome
based on the number of shared cases.
Similar with more cases:
- Other extrapyramidal and movement disorders in other diseases
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22541 | 14134 | 8331 |
| Only index persons | 21977 | 13876 | 8101 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.34 | 0.40 | 0.23 |
| Only index persons | 0.44 | 0.51 | 0.31 |
| Median age at first event (years) | |||
| Whole population | 64.52 | 65.47 | 63.04 |
| Only index persons | 64.47 | 65.40 | 62.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3850 | 2538 | 1312 |
| Unadjusted period prevalence (%) | 0.88 | 1.00 | 0.66 |
| Median age at first event (years) | 62.47 | 61.61 | 64.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_RLS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_RLS | 1.061 [0.92, 1.23] | 0.425 |
| Birth year | 0.993 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 1342 out of 10279 females with G6_RLS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_RLS | 1.246 [1.07, 1.45] | 0.004 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 1193 out of 6145 males with G6_RLS died.
Mortality risk
Mortality risk for people of age
years, who have G6_RLS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.061% | 0.23% |
| 5 | 0.57% | 1.436% |
| 10 | 1.463% | 3.607% |
| 15 | 2.728% | 6.773% |
| 20 | 4.931% | 11.498% |
Relationships between endpoints
↥Index endpoint: G6_RLS – Restless leg syndrome
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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