No definition available.
Systemic atrophies primarily affecting the central nervous system
DOID EFO Endpoint Browser PheWeb
G6_NEUATR
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1173 |
4. Check minimum number of eventsNone |
1173 |
5. Include endpoints |
1346 |
6. Filter based on genotype QC (FinnGen only) |
1305 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Systemic atrophies primarily affecting the central nervous system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16815 | 7755 | 8724 |
| Only index persons | 10265 | 4914 | 5351 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.22 | 0.24 |
| Only index persons | 0.19 | 0.18 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 61.80 | 62.97 | 60.68 |
| Only index persons | 60.13 | 60.86 | 59.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1305 | 555 | 750 |
| Unadjusted period prevalence (%) | 0.31 | 0.22 | 0.38 |
| Median age at first event (years) | 61.81 | 59.57 | 63.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_NEUATR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUATR | 7.442 [6.44, 8.6] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.176 |
During the follow-up period (1.1.1998 — 31.12.2019), 2750 out of 4587 females with G6_NEUATR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUATR | 5.431 [4.76, 6.19] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 3012 out of 5076 males with G6_NEUATR died.
Mortality risk
Mortality risk for people of age
years, who have G6_NEUATR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.823% | 0.863% |
| 5 | 3.911% | 5.649% |
| 10 | 10.404% | 14.121% |
| 15 | 19.039% | 26.114% |
| 20 | 31.816% | 40.692% |
Relationships between endpoints
↥Index endpoint: G6_NEUATR – Systemic atrophies primarily affecting the central nervous system
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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