motor neuron disease: A disease involving the motor neuron.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
603 |
4. Check minimum number of eventsNone |
603 |
5. Include endpointsNone |
603 |
6. Filter based on genotype QC (FinnGen only) |
591 |
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G12
Name in latin
Morbus motoneuronalis
Similar endpoints
↥List of similar endpoints to
Motor neuron disease
based on the number of shared cases.
Similar with more cases:
- Motor neuron disease (with DMD)
- Systemic atrophies primarily affecting the central nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8362 | 3928 | 4249 |
| Only index persons | 4490 | 2114 | 2376 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.11 | 0.12 |
| Only index persons | 0.08 | 0.08 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 66.30 | 67.33 | 65.35 |
| Only index persons | 67.14 | 68.36 | 66.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 591 | 240 | 351 |
| Unadjusted period prevalence (%) | 0.14 | 0.09 | 0.18 |
| Median age at first event (years) | 67.39 | 67.44 | 67.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALS | 18.515 [14.27, 24.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.318 |
During the follow-up period (1.1.1998 — 31.12.2019), 2037 out of 2507 females with G6_ALS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALS | 9.357 [7.48, 11.7] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.04 |
During the follow-up period (1.1.1998 — 31.12.2019), 1983 out of 2612 males with G6_ALS died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.608% | 1.809% |
| 5 | 9.35% | 11.766% |
| 10 | 22.668% | 26.493% |
| 15 | 41.38% | 44.597% |
| 20 | 62.462% | 65.032% |
Relationships between endpoints
↥Index endpoint: G6_ALS – Motor neuron disease
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data