No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
109 |
4. Check minimum number of eventsNone |
109 |
5. Include endpointsNone |
109 |
6. Filter based on genotype QC (FinnGen only) |
107 |
Control definitions (FinnGen only)
Control exclude
G6_AUTONOM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90
Name in latin
Neuropathia autonomica peripherica idiopathica
Similar endpoints
↥List of similar endpoints to
Idiopathic peripheral autonomic neuropathy
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 941 | 432 | 497 |
| Only index persons | 774 | 372 | 402 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 57.97 | 60.25 | 55.86 |
| Only index persons | 55.19 | 57.82 | 52.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 107 | 56 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 61.75 | 61.09 | 62.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_IDIOAUT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_IDIOAUT | 2.777 [2.01, 3.83] | < 0.001 |
| Birth year | 0.994 [0.98, 1.01] | 0.307 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 females with G6_IDIOAUT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_IDIOAUT | 1.888 [1.43, 2.49] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 429 males with G6_IDIOAUT died.
Mortality risk
Mortality risk for people of age
years, who have G6_IDIOAUT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.284% | 0.399% |
| 5 | 1.651% | 2.298% |
| 10 | 4.088% | 5.4% |
| 15 | 7.869% | 10.144% |
| 20 | 13.603% | 17.063% |
Relationships between endpoints
↥Index endpoint: G6_IDIOAUT – Idiopathic peripheral autonomic neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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