No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
401 |
4. Check minimum number of eventsNone |
401 |
5. Include endpointsNone |
401 |
6. Filter based on genotype QC (FinnGen only) |
392 |
Control definitions (FinnGen only)
Control exclude
G6_AUTONOM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90
Name in latin
Syndroma Horner
Similar endpoints
↥List of similar endpoints to
Horner syndrome
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2743 | 1372 | 1366 |
| Only index persons | 2515 | 1258 | 1257 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 52.54 | 54.09 | 50.94 |
| Only index persons | 52.78 | 54.46 | 51.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 392 | 216 | 176 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.09 |
| Median age at first event (years) | 55.37 | 55.41 | 55.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_HORNER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HORNER | 1.65 [1.36, 2.0] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.712 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 1204 females with G6_HORNER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HORNER | 1.362 [1.12, 1.65] | 0.002 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 172 out of 1188 males with G6_HORNER died.
Mortality risk
Mortality risk for people of age
years, who have G6_HORNER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.154% | 0.27% |
| 5 | 0.995% | 1.74% |
| 10 | 2.61% | 4.415% |
| 15 | 5.056% | 8.223% |
| 20 | 9.002% | 13.224% |
Relationships between endpoints
↥Index endpoint: G6_HORNER – Horner syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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