acute chest syndrome: A vaso-occlusive crisis of the pulmonary vasculature occurring in patients with sickle cell disease. It is characterized by the presence of a new radiodensity on a chest radiograph accompanied by fever, cough, sputum production, dyspnea, or hypoxia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
20315 |
4. Check minimum number of eventsNone |
20315 |
5. Include endpoints |
20393 |
6. Filter based on genotype QC (FinnGen only) |
19486 |
Control definitions (FinnGen only)
Control exclude
G6_EPIPAROX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G40-G47
Name in latin
Alia syndromata cephalalgica
Similar endpoints
↥List of similar endpoints to
Other headache syndromes
based on the number of shared cases.
Similar with more cases:
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 154528 | 105035 | 48504 |
| Only index persons | 148177 | 101758 | 46419 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.48 | 3.01 | 1.36 |
| Only index persons | 3.12 | 3.74 | 1.77 |
| Median age at first event (years) | |||
| Whole population | 46.78 | 47.56 | 45.27 |
| Only index persons | 46.33 | 47.06 | 44.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19486 | 14317 | 5169 |
| Unadjusted period prevalence (%) | 4.82 | 5.62 | 2.60 |
| Median age at first event (years) | 48.42 | 47.02 | 52.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_HEADACHE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HEADACHE | 1.005 [0.93, 1.09] | 0.909 |
| Birth year | 0.996 [0.99, 1.0] | 0.371 |
During the follow-up period (1.1.1998 — 31.12.2019), 9499 out of 93686 females with G6_HEADACHE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HEADACHE | 1.013 [0.93, 1.1] | 0.756 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 5257 out of 42956 males with G6_HEADACHE died.
Mortality risk
Mortality risk for people of age
years, who have G6_HEADACHE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.182% |
| 5 | 0.573% | 1.238% |
| 10 | 1.556% | 3.175% |
| 15 | 2.963% | 6.0% |
| 20 | 5.168% | 9.932% |
Relationships between endpoints
↥Index endpoint: G6_HEADACHE – Other headache syndromes
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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