No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
611 |
4. Check minimum number of eventsNone |
611 |
5. Include endpointsNone |
611 |
6. Filter based on genotype QC (FinnGen only) |
589 |
Control definitions (FinnGen only)
Control exclude
G6_HYDROCEPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6159 | 3013 | 3080 |
| Only index persons | 4640 | 2370 | 2270 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.09 | 0.09 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 56.12 | 58.51 | 53.59 |
| Only index persons | 54.55 | 57.40 | 51.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 589 | 322 | 267 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | 60.29 | 57.90 | 63.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCOTHUNS | 3.018 [2.63, 3.46] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.569 |
During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 2228 females with G6_HCOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCOTHUNS | 3.131 [2.67, 3.68] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 826 out of 2254 males with G6_HCOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.299% | 0.595% |
| 5 | 2.223% | 3.345% |
| 10 | 5.219% | 8.599% |
| 15 | 10.012% | 15.221% |
| 20 | 16.312% | 24.269% |
Relationships between endpoints
↥Index endpoint: G6_HCOTHUNS – Other and unspecified hydrocephalus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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