No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
516 |
4. Check minimum number of eventsNone |
516 |
5. Include endpointsNone |
516 |
6. Filter based on genotype QC (FinnGen only) |
501 |
Control definitions (FinnGen only)
Control exclude
G6_HYDROCEPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G91
Name in latin
Hydrocephalia obstructiva
Similar endpoints
↥List of similar endpoints to
Obstructive hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5759 | 2782 | 2921 |
| Only index persons | 4149 | 2069 | 2080 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 50.19 | 53.09 | 47.07 |
| Only index persons | 46.90 | 51.02 | 42.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 501 | 259 | 242 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 54.51 | 51.71 | 57.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCOBSTR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCOBSTR | 4.198 [3.58, 4.93] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.317 |
During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 1803 females with G6_HCOBSTR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCOBSTR | 4.142 [3.49, 4.92] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 664 out of 1881 males with G6_HCOBSTR died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCOBSTR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.303% | 0.858% |
| 5 | 2.097% | 4.966% |
| 10 | 5.729% | 12.13% |
| 15 | 11.161% | 22.418% |
| 20 | 19.411% | 35.9% |
Relationships between endpoints
↥Index endpoint: G6_HCOBSTR – Obstructive hydrocephalus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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