normal pressure hydrocephalus: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1593 |
4. Check minimum number of eventsNone |
1593 |
5. Include endpointsNone |
1593 |
6. Filter based on genotype QC (FinnGen only) |
1553 |
Control definitions (FinnGen only)
Control exclude
G6_HYDROCEPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G91
Name in latin
Hydrocephalia normotensiva
Similar endpoints
↥List of similar endpoints to
Normal-pressure hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8138 | 4029 | 4003 |
| Only index persons | 6703 | 3428 | 3275 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.12 | 0.11 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 74.05 | 74.92 | 73.17 |
| Only index persons | 73.83 | 74.66 | 72.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1553 | 729 | 824 |
| Unadjusted period prevalence (%) | 0.35 | 0.29 | 0.41 |
| Median age at first event (years) | 73.01 | 73.25 | 72.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCNP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCNP | 2.238 [2.01, 2.49] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.32 |
During the follow-up period (1.1.1998 — 31.12.2019), 1631 out of 3345 females with G6_HCNP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCNP | 2.381 [2.07, 2.74] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1722 out of 3293 males with G6_HCNP died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCNP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.473% |
| 5 | 1.38% | 2.537% |
| 10 | 3.1% | 6.356% |
| 15 | 6.083% | 11.522% |
| 20 | 11.154% | 18.816% |
Relationships between endpoints
↥Index endpoint: G6_HCNP – Normal-pressure hydrocephalus
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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