brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
174 |
4. Check minimum number of eventsNone |
174 |
5. Include endpointsNone |
174 |
6. Filter based on genotype QC (FinnGen only) |
170 |
Control definitions (FinnGen only)
Control exclude
G6_HYDROCEPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Hydrocephalus in other diseases
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1769 | 924 | 839 |
| Only index persons | 1488 | 795 | 693 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 56.83 | 58.92 | 54.41 |
| Only index persons | 57.38 | 58.88 | 55.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 170 | 108 | 62 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 59.80 | 59.20 | 60.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.144 [3.85, 6.87] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 238 out of 716 females with G6_HCINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.443 [3.94, 7.52] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 203 out of 639 males with G6_HCINOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.386% | 0.987% |
| 5 | 3.0% | 6.198% |
| 10 | 6.745% | 15.626% |
| 15 | 12.709% | 27.03% |
| 20 | 20.651% | 42.374% |
Relationships between endpoints
↥Index endpoint: G6_HCINOTH – Hydrocephalus in other diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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