No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
696 |
4. Check minimum number of eventsNone |
696 |
5. Include endpointsNone |
696 |
6. Filter based on genotype QC (FinnGen only) |
679 |
Control definitions (FinnGen only)
Control exclude
G6_HYDROCEPH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G91
Name in latin
Hydrocephalia communicans
Similar endpoints
↥List of similar endpoints to
Communicating hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6750 | 3351 | 3305 |
| Only index persons | 4677 | 2460 | 2217 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.09 |
| Only index persons | 0.09 | 0.09 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 59.21 | 61.43 | 56.68 |
| Only index persons | 55.27 | 58.24 | 51.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 679 | 348 | 331 |
| Unadjusted period prevalence (%) | 0.15 | 0.14 | 0.17 |
| Median age at first event (years) | 59.89 | 59.57 | 60.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCCOMM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCCOMM | 3.207 [2.83, 3.63] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.446 |
During the follow-up period (1.1.1998 — 31.12.2019), 862 out of 2207 females with G6_HCCOMM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCCOMM | 3.268 [2.82, 3.79] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 835 out of 2089 males with G6_HCCOMM died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCCOMM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.237% | 0.734% |
| 5 | 1.673% | 3.6% |
| 10 | 4.418% | 9.74% |
| 15 | 9.011% | 17.976% |
| 20 | 15.437% | 29.439% |
Relationships between endpoints
↥Index endpoint: G6_HCCOMM – Communicating hydrocephalus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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