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Other and unspecified disorders of autonomic nervous system

DOID EFO Endpoint Browser PheWeb

G6_AUTOTHUNS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G90.8, G90.9
  • Hospital discharge: ICD-9 — 337[1-9]
  • Cause of death: ICD-10 — G90.8, G90.9
  • Cause of death: ICD-9 — 337[1-9]

2 out of 7 registries used, show all original rules.

110

4. Check minimum number of events

None

110

5. Include endpoints

None

110

6. Filter based on genotype QC (FinnGen only)

107

Control definitions (FinnGen only)

Control exclude G6_AUTONOM

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1130 550 569
Only index persons 923 477 446
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.73 48.91 52.18
Only index persons 48.28 47.06 49.57

-FinnGen-

Key figures

All Female Male
Number of individuals 107 60 47
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 46.97 43.25 51.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint G6_AUTOTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_AUTOTHUNS 2.676 [1.8, 3.98] < 0.001
Birth year 0.995 [0.99, 1.0] 0.258

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 362 females with G6_AUTOTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_AUTOTHUNS 2.681 [2.0, 3.6] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 402 males with G6_AUTOTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_AUTOTHUNS.

N-year risk Females Males
1 0.252% 0.419%
5 1.563% 3.014%
10 3.867% 7.291%
15 7.165% 13.851%
20 12.414% 22.741%

Relationships between endpoints

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Index endpoint: G6_AUTOTHUNS – Other and unspecified disorders of autonomic nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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