No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
80 |
4. Check minimum number of eventsNone |
80 |
5. Include endpointsNone |
80 |
6. Filter based on genotype QC (FinnGen only) |
76 |
Control definitions (FinnGen only)
Control exclude
F5_MENTRET
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F70-F79
Name in latin
Retardatio mentalis gravis
Similar endpoints
↥List of similar endpoints to
Severe mental retardation
based on the number of shared cases.
Similar with more cases:
- Mental retardation
- Mental retardation
- Mental retardation
- Psychiatric diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5092 | 2194 | 2897 |
| Only index persons | 4034 | 1735 | 2299 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.08 |
| Only index persons | 0.08 | 0.06 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 23.02 | 24.33 | 22.03 |
| Only index persons | 22.29 | 23.33 | 21.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 76 | 32 | 44 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 24.96 | 15.89 | 31.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint F5_SEVRET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SEVRET | 7.236 [4.69, 11.16] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.367 |
During the follow-up period (1.1.1998 — 31.12.2019), 263 out of 981 females with F5_SEVRET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SEVRET | 5.907 [4.34, 8.03] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.091 |
During the follow-up period (1.1.1998 — 31.12.2019), 324 out of 1391 males with F5_SEVRET died.
Mortality risk
Mortality risk for people of age
years, who have F5_SEVRET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.712% | 1.176% |
| 5 | 4.535% | 7.074% |
| 10 | 9.503% | 17.82% |
| 15 | 18.507% | 31.6% |
| 20 | 31.77% | 46.652% |
Relationships between endpoints
↥Index endpoint: F5_SEVRET – Severe mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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