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Schizoid personality disorder

DOID EFO Endpoint Browser PheWeb

F5_SCHIZPER

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F60.1
  • Hospital discharge: ICD-9 — 3012
  • Hospital discharge: ICD-8 — 3012
  • Cause of death: ICD-10 — F60.1
  • Cause of death: ICD-9 — 3012
  • Cause of death: ICD-8 — 3012

2 out of 7 registries used, show all original rules.

639

4. Check minimum number of events

None

639

5. Include endpoints

None

639

6. Filter based on genotype QC (FinnGen only)

614

Control definitions (FinnGen only)

Control exclude F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F60
Name in latin Personalitas schizoides

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6590 2151 4380
Only index persons 5602 1896 3706
Unadjusted period prevalence (%)
Whole population 0.10 0.06 0.12
Only index persons 0.12 0.07 0.14
Median age at first event (years)
Whole population 32.09 34.37 30.82
Only index persons 31.55 33.83 30.38

-FinnGen-

Key figures

All Female Male
Number of individuals 614 240 374
Unadjusted period prevalence (%) 0.15 0.09 0.19
Median age at first event (years) 31.64 33.09 30.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint F5_SCHIZPER and mortality.

Females

Parameter HR [95% CI] p-value
F5_SCHIZPER 3.098 [2.45, 3.92] < 0.001
Birth year 0.994 [0.99, 1.0] 0.156

During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 1025 females with F5_SCHIZPER died.

Males

Parameter HR [95% CI] p-value
F5_SCHIZPER 2.607 [2.21, 3.07] < 0.001
Birth year 0.988 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 1867 males with F5_SCHIZPER died.

Mortality risk

Mortality risk for people of age

years, who have F5_SCHIZPER.

N-year risk Females Males
1 0.197% 0.405%
5 1.649% 2.752%
10 4.044% 7.078%
15 7.98% 13.515%
20 14.365% 22.207%

Relationships between endpoints

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Index endpoint: F5_SCHIZPER – Schizoid personality disorder

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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