Other and unspecified disorders of adult personality and behaviour

F5_PERSOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F68, F69
  • Cause of death: ICD-10 F68, F69

2 out of 7 registries used, show all original rules.

200

4. Check minimum number of events

None

200

5. Include endpoints

None

200

6. Filter based on genotype QC (FinnGen only)

194

Control definitions (FinnGen only)

Control exclude F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2012 998 1001
Only index persons 1845 947 898
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 30.95 30.95 30.80
Only index persons 29.81 29.99 29.62

-FinnGen-

Key figures

All Female Male
Number of individuals 194 131 63
Unadjusted period prevalence (%) 0.05 0.05 0.03
Median age at first event (years) 33.97 32.19 37.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint F5_PERSOTH and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERSOTH 3.96 [2.86, 5.48] < 0.001
Birth year 0.997 [0.99, 1.01] 0.546

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 874 females with F5_PERSOTH died.

Males

Parameter HR [95% CI] p-value
F5_PERSOTH 3.707 [2.77, 4.95] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 154 out of 864 males with F5_PERSOTH died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERSOTH.

N-year risk Females Males
1 0.438% 0.701%
5 2.464% 4.344%
10 5.706% 9.585%
15 10.864% 17.3%
20 18.266% 27.732%

Relationships between endpoints

Index endpoint: F5_PERSOTH – Other and unspecified disorders of adult personality and behaviour

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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