No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
140 |
4. Check minimum number of eventsNone |
140 |
5. Include endpointsNone |
140 |
6. Filter based on genotype QC (FinnGen only) |
133 |
Control definitions (FinnGen only)
Control exclude
F5_PERSOBEH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F60-F62
Name in latin
Commutationes personalitatis persistentes non laesioni neque morbo cerebri ascribendae
Similar endpoints
↥List of similar endpoints to
Enduring personality changes
based on the number of shared cases.
Similar with more cases:
- Disorders of adult personality and behaviour
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1229 | 593 | 625 |
| Only index persons | 1114 | 557 | 557 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 43.28 | 42.70 | 43.81 |
| Only index persons | 42.94 | 42.65 | 43.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 133 | 75 | 58 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 45.80 | 43.28 | 49.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint F5_PERSOCHANGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSOCHANGE | 3.327 [2.45, 4.53] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 515 females with F5_PERSOCHANGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSOCHANGE | 2.806 [2.0, 3.94] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 545 males with F5_PERSOCHANGE died.
Mortality risk
Mortality risk for people of age
years, who have F5_PERSOCHANGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.292% | 0.583% |
| 5 | 1.694% | 3.167% |
| 10 | 4.18% | 7.849% |
| 15 | 7.833% | 15.454% |
| 20 | 14.019% | 26.046% |
Relationships between endpoints
↥Index endpoint: F5_PERSOCHANGE – Enduring personality changes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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