mood disorder: A cognitive disorder a disturbance in which the person's mood is hypothesized to be the main underlying feature.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8428 |
4. Check minimum number of eventsNone |
8428 |
5. Include endpointsNone |
8428 |
6. Filter based on genotype QC (FinnGen only) |
8142 |
Control definitions (FinnGen only)
Control exclude
F5_MOOD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F30-F39
Name in latin
Perturbationes affectivae persistentes
Similar endpoints
↥List of similar endpoints to
Persistent mood disorders
based on the number of shared cases.
Similar with more cases:
- Mood [affective] disorders
- Mood disorders
- Mood disorders
- Affective disorder, aux endpoint for F5_SAD
- Any mental disorder
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 90967 | 53125 | 36825 |
| Only index persons | 70196 | 42613 | 27583 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.32 | 1.52 | 1.03 |
| Only index persons | 1.36 | 1.57 | 1.05 |
| Median age at first event (years) | |||
| Whole population | 41.00 | 43.27 | 37.61 |
| Only index persons | 37.84 | 39.80 | 34.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8142 | 5234 | 2908 |
| Unadjusted period prevalence (%) | 1.84 | 2.06 | 1.46 |
| Median age at first event (years) | 39.30 | 38.90 | 40.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_PERSMOOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSMOOD | 1.839 [1.67, 2.03] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.209 |
During the follow-up period (1.1.1998 — 31.12.2019), 2875 out of 24586 females with F5_PERSMOOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSMOOD | 2.206 [1.99, 2.45] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2320 out of 14507 males with F5_PERSMOOD died.
Mortality risk
Mortality risk for people of age
years, who have F5_PERSMOOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.17% | 0.437% |
| 5 | 1.068% | 2.671% |
| 10 | 2.709% | 6.155% |
| 15 | 5.051% | 11.32% |
| 20 | 8.806% | 18.812% |
Relationships between endpoints
↥Index endpoint: F5_PERSMOOD – Persistent mood disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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