mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
534 |
4. Check minimum number of eventsNone |
534 |
5. Include endpointsNone |
534 |
6. Filter based on genotype QC (FinnGen only) |
486 |
Control definitions (FinnGen only)
Control exclude
F5_MENTRET
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified mental retardation
based on the number of shared cases.
Similar with more cases:
- Mental retardation
- Mental retardation
- Mental retardation
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16429 | 6793 | 9614 |
| Only index persons | 12801 | 5334 | 7467 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.19 | 0.27 |
| Only index persons | 0.25 | 0.20 | 0.29 |
| Median age at first event (years) | |||
| Whole population | 7.92 | 9.25 | 6.90 |
| Only index persons | 9.82 | 11.70 | 8.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 486 | 223 | 263 |
| Unadjusted period prevalence (%) | 0.11 | 0.09 | 0.13 |
| Median age at first event (years) | 10.49 | 12.81 | 8.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint F5_OTHRET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_OTHRET | 5.514 [4.46, 6.81] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 447 out of 3621 females with F5_OTHRET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_OTHRET | 4.418 [3.68, 5.31] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 509 out of 5439 males with F5_OTHRET died.
Mortality risk
Mortality risk for people of age
years, who have F5_OTHRET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.518% | 1.017% |
| 5 | 2.797% | 5.521% |
| 10 | 7.457% | 12.32% |
| 15 | 14.119% | 20.931% |
| 20 | 23.79% | 32.784% |
Relationships between endpoints
↥Index endpoint: F5_OTHRET – Other and unspecified mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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