mood disorder: A cognitive disorder a disturbance in which the person's mood is hypothesized to be the main underlying feature.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2884 |
4. Check minimum number of eventsNone |
2884 |
5. Include endpointsNone |
2884 |
6. Filter based on genotype QC (FinnGen only) |
2735 |
Control definitions (FinnGen only)
Control exclude
F5_MOOD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Other and unspecified mood [affective] disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 28135 | 16687 | 11246 |
| Only index persons | 26444 | 15949 | 10495 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.41 | 0.48 | 0.31 |
| Only index persons | 0.51 | 0.59 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 31.17 | 30.13 | 32.63 |
| Only index persons | 30.35 | 29.41 | 31.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2735 | 1873 | 862 |
| Unadjusted period prevalence (%) | 0.64 | 0.74 | 0.43 |
| Median age at first event (years) | 35.19 | 33.22 | 39.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_MOODOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MOODOTH | 2.466 [2.12, 2.87] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 960 out of 13079 females with F5_MOODOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MOODOTH | 2.829 [2.42, 3.3] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 980 out of 8862 males with F5_MOODOTH died.
Mortality risk
Mortality risk for people of age
years, who have F5_MOODOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.173% | 0.476% |
| 5 | 1.161% | 3.054% |
| 10 | 3.187% | 7.478% |
| 15 | 5.888% | 14.067% |
| 20 | 10.661% | 23.453% |
Relationships between endpoints
↥Index endpoint: F5_MOODOTH – Other and unspecified mood [affective] disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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